Dihydrocoumarin ọ na-egbu egbu

Dihydrocoumarin, ihe na-esi ísì ụtọ, nke a na-eji eme nri, a na-ejikwa ya dị ka ihe nnọchi coumarin, nke a na-eji dị ka ihe ịchọ mma; ude agwakọtara, aki oyibo, ụtọ sinamọn; A na-ejikwa ya dị ka ihe na-esi ísì ụtọ ụtaba.

Dihydrocoumarin ọ na-egbu egbu

Dihydrocoumarin anaghị egbu egbu. Dihydrocoumarin bụ ngwaahịa eke a na-ahụ na rhino vanilla odo odo. A na-akwadebe ya site na hydrogenation nke coumarin n'ihu ihe na-eme ka nickel na-akpali akpali na 160-200 ℃ ma nwee nrụgide. Enwere ike iji ya dị ka ihe eji emepụta ihe, gbanye ya na mmiri alkaline iji mepụta o-hydroxyphenylpropionic acid, kpọnwụọ ya, wee mechie ya.

Ọnọdụ nchekwa

E mechiri emechi ma gbaa ọchịchịrị, echekwara ya n'ebe dị jụụ ma kpọọ nkụ, oghere dị n'ime gbọmgbọm ahụ dị obere dịka o kwere mee n'ihi ikike nchekwa, a jupụtakwara ya na nchekwa nitrogen. Debe ya n'ụlọ nkwakọba ihe dị jụụ ma nwee ikuku. Zere ọkụ, mmiri. A ga-echekwa ya iche na ihe na-eme ka ọ dị ọcha, agwakọtala ebe nchekwa. Ejiri ụdị na ọnụọgụ ngwa ọkụ kwekọrọ na ya.

Ọmụmụ ihe n'ime vitro

Nnyocha enzymatic in vitro, dihydrocoumarin butere mgbochi dabere na njupụta nke SIRT1 (IC50 nke 208μM). A hụrụ mbelata na ọrụ deacetylase SIRT1 ọbụlagodi na doses micromolar (ọrụ 85±5.8 na 73± 13.7% na 1.6μM na 8μM, n'otu n'otu). E gbochikwara microtubule SIRT2 deacetylase n'ụzọ yiri nke ahụ dabere na dose (IC50 nke 295μM).

Mgbe awa iri abụọ na anọ nke mkpughe gasịrị, dihydrocoumarin (1-5mM) mụbara nsí cytotoxicity na ahịrị mkpụrụ ndụ TK6 n'ụzọ dabere na dose. Dihydrocoumarin (1-5mM) mụbara apoptosis na ahịrị mkpụrụ ndụ TK6 n'ụzọ dabere na dose na oge awa isii. Ọgwụ dihydrocoumarin nke 5mM mụbara apoptosis na oge awa isii na ahịrị mkpụrụ ndụ TK6. Mgbe oge mkpughe nke awa iri abụọ na anọ gasịrị, dihydrocoumarin (1-5mM) mụbara p53 lysine 373 na 382 acetylation n'ụzọ dabere na dose na ahịrị mkpụrụ ndụ TK6.