Dihydrocoumarin na-egbu egbu

Dihydrocoumarin, ihe na-esi ísì ụtọ, nke a na-eji na nri, a na-ejikwa ya dochie anya coumarin, nke a na-eji dị ka ekpomeekpo ịchọ mma; Gwakọta ude, aki oyibo, ụtọ cinnamon; A na-ejikwa ya dị ka ụtọ ụtaba.

Dihydrocoumarin na-egbu egbu

Dihydrocoumarin adịghị egbu egbu. Dihydrocoumarin bụ ngwaahịa ebumpụta ụwa nke achọtara na rhinoceros vanilla odo. A na-akwado ya site na hydrogenation nke coumarin na ọnụnọ nickel catalyst na 160-200 ℃ na nrụgide. A pụkwara iji ya mee ihe dị ka akụrụngwa, hydrolyzed na alkaline aqueous ngwọta na-emepụta o-hydroxyphenylpropionic acid, akpịrị ịkpọ nkụ, mechiri emechi-loop nwetara.

Ọnọdụ nchekwa

Na-emechi na ọchịchịrị, echekwara na ebe dị jụụ na akọrọ, ohere dị na gbọmgbọm dị ntakịrị dị ka o kwere mee n'okpuru ikike nchekwa, ma jupụta na nchebe nitrogen. Chekwaa n'ụlọ nkwakọba ihe dị jụụ, ikuku ikuku. Zere ọkụ, mmiri. Ekwesịrị ịchekwa ya iche na oxidizer, agwakọtala nchekwa. Ejiri ụdị ọkụ dị iche iche kwekọrọ na ọnụọgụ ngwa ọkụ.

Ọmụmụ in vitro

In vitro enzymatic assay, dihydrocoumarin butere mgbochi dabere na SIRT1 (IC50 nke 208μM). Mbelata na SIRT1 deacetylase ọrụ ka hụrụ ọbụna na micromolar doses (85 ± 5.8 na 73 ± 13.7% ọrụ na 1.6μM na 8μM n'otu n'otu). A gbochiri Microtubule SIRT2 deacetylase n'ụdị dabere na dose (IC50 nke 295μM).

Mgbe awa 24 gachara, dihydrocoumarin (1-5mM) mụbara cytotoxicity na ahịrị sel TK6 n'ụzọ dabere na dose. Dihydrocoumarin (1-5mM) mụbara apoptosis na ahịrị sel TK6 n'ụzọ dabere na dose na oge awa 6. Ngwunye 5mM nke dihydrocoumarin mụbara apoptosis n'oge awa 6 n'ahịrị cell TK6. Mgbe oge ikpughe awa 24 gachara, dihydrocoumarin (1-5mM) mụbara p53 lysine 373 na 382 acetylation n'ụzọ dabere na dose na eriri cell TK6.