A maara ya n'otu oge dị ka "ọlaedo na-acha ọcha", aha ya na-adaberekwa na mmetụta ọcha ya na-enweghị atụ n'otu aka, na ihe isi ike na ụkọ nke mmịpụta ya n'akụkụ nke ọzọ.Osisi Glycyrrhiza glabra bụ isi iyi nke Glabridin, mana Glabridin bụ naanị 0.1% -0.3% nke ọdịnaya ya n'ozuzu ya, ya bụ, 1000kg nke Glycyrrhiza glabra nwere ike nweta naanị 100g.Glabridin, 1g nke Glabridin dabara na 1g nke ọla edo nkịtị.
Hikarigandine bụ ihe nnọchianya nke ihe ọkụkụ ahịhịa, na Japan na-achọpụta mmetụta ọcha ya
Glycyrrhiza glabra bụ osisi nke genus Glycyrrhiza.China bụ obodo nwere akụ ahịhịa kacha baa ọgaranya n'ụwa, enwerekwa ihe karịrị ụdị herbs 500 ndị a na-eji eme ihe n'ụlọ ọgwụ, n'ime nke a na-ejikarị bụ licorice.Dị ka ọnụ ọgụgụ si kwuo, ọnụ ọgụgụ ojiji nke licorice karịrị 79%.
N'ihi ogologo akụkọ ihe mere eme nke ngwa, na-esonyere ya na aha dị elu, ọnụọgụ nyocha banyere uru nke licorice ọ bụghị nanị na-agbaji site na njedebe mpaghara, kamakwa ngwa ahụ gbasaa.Dị ka nchọpụta si kwuo, ndị na-azụ ahịa na Eshia, karịsịa na Japan, nwere nkwanye ùgwù dị ukwuu maka ihe ịchọ mma nwere ihe ọkụkụ na-arụ ọrụ.Edekọla ihe ịchọ mma herbal 114 n'ime "Japan's General Cosmetics Raw Materials", enweelarị ụdị ịchọ mma 200 nwere ihe ọkụkụ na Japan.
Aghọtara na ọ nwere mmetụta ịcha ọcha nke ukwuu, mana kedu ihe isi ike dị na ngwa bara uru?
Akụkụ hydrophobic nke licorice wepụ nwere flavonoids dị iche iche.Dị ka akụkụ bụ isi nke akụkụ hydrophobic ya, halo-glycyrrhizidine nwere mmetụta mgbochi na mmepụta melanin ma nwee mmetụta mgbochi mkpali na mgbochi oxidant.
Ụfọdụ data nnwale na-egosi na mmetụta nke ìhè Glabridin na-acha ọcha dị elu ugboro 232 karịa nke vitamin C nkịtị, ugboro 16 dị elu karịa nke hydroquinone, yana 1,164 ugboro karịa nke arbutin.Na otu esi enweta ọrụ ịcha ọcha siri ike, ọkụ Glabridin na-enye ụzọ atọ dị iche iche.
1. Mgbochi nke ọrụ tyrosinase
Isi whitening usoro nkeGlabridinbụ igbochi njikọ nke melanin site na ịsọ mpi igbochi ọrụ tyrosinase, wepụ akụkụ nke tyrosinase na mgbanaka catalytic nke melanin njikọ na igbochi njikọ nke mkpụrụ na tyrosinase.
2. Mmetụta antioxidant
Ọ nwere ike igbochi ma ọrụ nke tyrosinase na dopa pigment mgbanwe yana ọrụ dihydroxyindole carboxylic acid oxidase.
E gosiputara na na ntinye nke 0.1mg / ml, photoglycyrrhizidine nwere ike ime ihe na cytochrome P450 / NADOH oxidation system na 67% nke radicals free, nke nwere ọrụ antioxidant siri ike.
3.Inhibit mkpali ihe na-alụ ọgụ megide UV
Ka ọ dị ugbu a, a kọwala obere nyocha banyere ojiji photoglycyrrhizidine na-amụ banyere ịse foto akpụkpọ anụ UV.N'afọ 2021, n'akwụkwọ akụkọ dị na akwụkwọ akụkọ bụ isi bụ Journal of Microbiology and Biotechnology, a mụrụ fotoglycyrrhizidine liposomes maka ike ha na-emeziwanye erythema UV na-akpata erythema na akpụkpọ anụ site na igbochi ihe ndị na-akpasu iwe.Photoglycyrrhizidine liposomes nwere ike iji melite bioavailability na obere cytotoxicity tinyere mma melanin mgbochi mma, n'ụzọ dị irè na-ebelata okwu nke mkpali cytokines, interleukin 6 na interleukin 10. Ya mere, a pụrụ iji ya dị ka onye na-ahụ maka ọgwụgwọ anụ ahụ iji gbochie mmebi akpụkpọ anụ UV radieshon. site na igbochi mbufụt, nke nwere ike inye ụfọdụ echiche maka nyocha nke ngwaahịa nchebe ìhè anyanwụ.
Na nchịkọta, a na-amata mmetụta na-acha ọcha nke photoglycyrrhizidine, ma ọdịdị nke ya fọrọ nke nta ka ọ bụrụ ihe na-adịghị edozi na mmiri, n'ihi ya, ọ na-achọsi ike maka mmepụta na mmepụta usoro na ntinye nke ngwaahịa nlekọta anụ ahụ, na ọ bụ ugbu a ngwọta dị mma site na liposome. teknụzụ encapsulation.Ọzọkwa, fotoGlabridinliposomes nwere ike igbochi fotoaging nke UV kpatara, mana ọrụ a chọrọ nnwale ụlọ ọgwụ ka ekwenye na ngwa nyocha ga-emejuputa.
Ngwaahịa nlekọta anụ ahụ nwere fotoGlabridin n'ụdị ngwakọta ihe.
Ọ bụ ezie na obi abụọ adịghị ya na fotoGlabridine nwere mmetụta dị ọcha nke ukwuu, ọnụahịa akụrụngwa ya bụkwa ihe mgbochi n'ihi ihe isi ike dị na mmịpụta na ọdịnaya.Na ịchọ mma R&D, ọrụ nke ịchịkwa ụgwọ na-ejikọta ya na ọdịnaya teknụzụ na usoro sayensị.Ya mere, ọ bụ ụzọ dị mma iji chịkwaa ọnụ ahịa nhazi na iji nweta mma dị mma ma dị irè site n'ịhọrọ ihe ndị na-arụ ọrụ na ijikọta ya na photoglycyrrhizidine.Na mgbakwunye na ọkwa R&D, a chọrọ nyocha ọzọ gbasara nyocha nke liposomes photoglycyrrhizidine na usoro mmịpụta kacha ọhụrụ.
Oge nzipu: Ọgọst-30-2022